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MMPs are believed to play a crucial role in degrading the extracellular matrix, with their activity thought to be finely balanced by TIMPs

Think lateral knee tissue, Achilles-adjacent fat pad, shoulder/deltoid-adjacent fat, or elbow-adjacent subcutaneous tissue

Pathological mechanisms of bortezomib-induced peripheral neuropathy

doi: 10.1002/pbc.27474

SURMOUNT-1 data shows that tirzepatide at the 10mg dose begins to plateau around 24 months as well, though higher doses may extend the active weight loss window somewhat further

Wegovy is strictly a weight loss drug, while Mounjaro and Ozempic are geared primarily toward diabetes treatment but also are prescribed for weight loss